Nitracrine
CAS No. : 4533-39-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $170 | In-stock |
| 10mg | $275 | In-stock |
| 25mg | $550 | In-stock |
| 50mg | $880 | In-stock |
| 100mg | $1410 | In-stock |
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| Cat. No. : | HY-U00279 |
| M.Wt: | 324.38 |
| Formula: | C18H20N4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Nitracrine inhibits RNA synthesis and covalently, reversibly binds to DNA but also forms covalent adducts with DNA in vivo. Nitracrine, a 1-nitroacridine derivative, is a potent hypoxia-selective agent in vitro and antitumor agent. Nitracrine has cytotoxicity towards most cells[1][2][3].
In Vitro:Nitracrine (2 μM; 1 hour) causes death of 50% of human erythroleukemia K562 cells under illumination for 48 min. While it is 8.5 hours for Nitracrine on the dark[3].
Nitracrine has LD50s of 0.23 μM, 0.6 μM, 0.16 μM in P388 cell, NIH3T3 cell, and K562 cells under illumination after 1 hour of cells incubation, respectively[3].
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