4-Methylcatechol

4-Methylcatechol is an intermediate in the degradation of some alkylbenzenes and an orally active suicide inhibitor of catechol 2,3-dioxygenase (C23O). 4-Methylcatechol induces apoptosis in melanoma cells through oxidative stress, but some studies have also shown that 4-Methylcatechol is carcinogenic. In addition, 4-Methylcatechol has antiplatelet and blood pressure-lowering activities. 4-Methylcatechol can also inhibit protein oxidation in beef but does not disulfide formation^{[1][2][3][4][5][6]}. In Vitro:4-Methylcatechol (0-25 μg/mL; 8 h-14 days) can inhibit the proliferation of melanoma cells, induce cell cycle arrest and induce apoptosis through the generation of reactive oxygen species through mitochondrial pathway^[1]. In Vivo:4-Methylcatechol (Feed management; 2%; 104 weeks) is carcinogenic to the forestomach and glandular stomach in F344 rats^[2].
4-Methylcatechol (Intravenous injection; 0.2-25 mg/kg; single dose) has vasodilatory and blood pressure-lowering effects in spontaneously hypertensive rats^[3].