H-Glu-OtBu


CAS No. : 45120-30-7

45120-30-7
Price and Availability of CAS No. : 45120-30-7
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5g $19 In-stock
10g $32 In-stock
25g $61 In-stock
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1000g $1831 In-stock
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Cat. No. : HY-W018154
M.Wt: 203.24
Formula: C9H17NO4
Purity: >98 %
Solubility: DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
Introduction of 45120-30-7 :

H-Glu-OtBu is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Glu-OtBu is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2 In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

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