R1487 (Hydrochloride)
CAS No. : 449808-64-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $126 | In-stock |
| 10mg | $190 | In-stock |
| 25mg | $380 | In-stock |
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| Cat. No. : | HY-14975 |
| M.Wt: | 424.83 |
| Formula: | C19H19ClF2N4O3 |
| Purity: | >98 % |
| Solubility: | H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : 20.83 mg/mL (ultrasonic) |
R1487 Hydrochloride is a highly potent and selective p38α inhibitor, with Kd values of 0.2 nM and 29 nM for p38α and p38β, respectively[1].
In Vitro: R1487 Hydrochloride exhibits IC50 values of 10 nM for p38α inhibition and 200 nM for the inhibition of TNFα induced production of IL-1β[1].
R1487 (Compounds 2a) inhibits production of TNFα by human monocytic cells (THP-1) and inhibits production of IL-1β in human whole blood (HWB) induced by LPS[1].
In Vivo: R1487 (Compounds 2a, orally) demonstrates significant dose-dependent inhibition of serum TNFα and IL-1β[1].
Oral bioavailability of 10 mg/kg R1487 (Compounds 2a) in monkey, rat, and dog was 51.6%, 29.3%, 10.3%, respectively[1].
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- R1487 (Hydrochloride)
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