Yoda 1
CAS No. : 448947-81-7
| Size | Price | Stock |
|---|---|---|
| 1mg | $51 | In-stock |
| 5mg | $108 | In-stock |
| 10mg | $144 | In-stock |
| 50mg | $576 | In-stock |
| 100mg | $1020 | In-stock |
| 250mg | $1500 | In-stock |
| 500mg | $2100 | In-stock |
| 1g | $2950 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-18723 |
| M.Wt: | 355.27 |
| Formula: | C13H8Cl2N4S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 15.62 mg/mL (ultrasonic;warming;heat to 60°C);Methanol : 2.5 mg/mL (ultrasonic);Ethanol : 5 mg/mL (ultrasonic) |
Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation[1][2][3].
IC50 & Target:Piezo1[1]
In Vitro:Yoda1 (0-6 μM, 5 min) induces the activation of both Akt and ERK1/2, which is not dependent on Piezo1[2].
Yoda1 (1.5 μM, 5 min) inhibits Rac1 activation[3].
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