NS1643
CAS No. : 448895-37-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $38 | In-stock |
| 10mg | $62 | In-stock |
| 25mg | $125 | In-stock |
| 50mg | $200 | In-stock |
| 100mg | $320 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-16916 |
| M.Wt: | 380.24 |
| Formula: | C15H10F6N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
NS1643 is a partial agonist of human ether-a-go-go-related gene (hERG) K+ channels with an EC50 of 10.5 μM. NS1643 inhibits the growth of breast cancer tumors in TNBC mouse models. NS1643 inhibits cell migration and invasion of breast cancer cells[1][2]. IC50 & Target:EC50: 10.5 μM (hERG) K+ channel[1] In Vitro:NS1643 (0-100 μM) dose- and voltage-dependently increases hERG current in oocytes[1]. NS1643 (3, 10 and 30 μM) slows the rate of hERG inactivation throughout the testing voltage range and reduces the extent of hERG channel rectification[1]. NS1643 (10 and 50 μM) dose-dependently inhibits cell migration and invasion of MDA-MB-231 and SKBR3 cancer cells[2]. In Vivo:NS1643 (6 mg/kg; i.p., twice per week) inhibits breast tumor metastasis[2].
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