SCH 336
CAS No. : 447459-51-0
(Synonyms: SCH-225336)
| Size | Price | Stock |
|---|---|---|
| 5mg | $130 | In-stock |
| 10mg | $210 | In-stock |
| 25mg | $353 | In-stock |
| 50mg | $520 | In-stock |
| 100mg | $750 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-121852 |
| M.Wt: | 539.64 |
| Formula: | C23H25NO8S3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
SCH 336 is a potent, selective, inverse and orally active CB2 agonist. SCH 336 inhibits BaF3/CB2 migration. SCH 336 significantly inhibits the migration of leukocytes in vivo. SCH 336 blocks ovalbumin-induced lung eosinophilia in mice[1].
In Vitro: SCH 336 (Sch.336) (0-10 µM) competes with [3H]CP55,940 for binding to human CB2 on Sf9 cell membranes with Ki of 1.8 nM, and decreases GTPγS binding on human CB2-containing membranes with an EC50 of 2 nM, decreases potency on CB1-containing membranes with EC50 of 200 nM[1].
SCH 336 inhibits BaF3/CB2 migration to 100 nM 2-AG with an IC50 of 34 nM[1].
In Vivo: SCH 336 (0.02, 0.2, 2.0 mg/kg; i.p.) significantly inhibits the migration of leukocytes[1].
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