RepSox (GMP)
CAS No. : 446859-33-2
(Synonyms: E-616452 (GMP); SJN 2511 (GMP))
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| Cat. No. : | HY-13012G |
| M.Wt: | 287.32 |
| Formula: | C17H13N5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
RepSox (E-616452) (GMP) is a RepSox (HY-13012) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. RepSox is a potent and selective TGF-β-RI/ALK5 inhibitor[1].
IC50 & Target:IC50: ALK5 autophosphorylation (4 nM)
In Vitro:RepSox (GMP) (10 μM) induces MEFs differentiating to chemically induced pluripotent stem cells (CiPSCs)[1].
RepSox (GMP) (10 μM, in stage I-Stage III induction medium) induces hCiPS cells from HEFs[2].
RepSox (GMP) together with Forskolin (HY-15371) increases the number of proliferative cells in MEFs expressing MyoD, confirmed by increased EdU incorporation[3].
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