KIN1400
CAS No. : 446826-86-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $225 | In-stock |
| 10 mg | Get quote | |
| 50 mg | Get quote | |
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| Cat. No. : | HY-123805 |
| M.Wt: | 449.47 |
| Formula: | C24H17F2N3O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 30 mg/mL (ultrasonic;warming) |
KIN1400 is a potent IRF3 activator. KIN1400 triggers IRF3-dependent innate immune antiviral genes (RIG-I, MDA5, IFIT1, and Mx1) and IFN-β expression. KIN1400 inhibits WNV and DV, two mosquito-borne members of the Flaviviridae and the genus Flavivirus. KIN1400 also inhibits HCV replication. KIN1400 induces innate antiviral immunity through a MAVS-IRF3 axis[1].
In Vitro:KIN1400 (0-20 μM, 20 h) induces the expression of the innate immune genes RIG-I (DDX58), IFIT1, and Mx1 in a dose-dependent fashion in PMA-differentiated THP-1 cells[1].
KIN1400 (0-20 μM, 24 h) suppresses WNV RNA levels is dose dependent in HEK293 cells, with 2 μM KIN1400 being sufficient to achieve a 50% or greater inhibition of WNV RNA levels[1].
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