YM-230888
CAS No. : 446257-23-4
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| Cat. No. : | HY-107510 |
| M.Wt: | 360.52 |
| Formula: | C19H28N4OS |
| Purity: | >98 % |
| Solubility: |
YM-230888 is an orally active, selective and allosteric mGlu1 receptor antagonist with a Ki of 13 nM. YM-230888 inhibits mGlu1-mediated inositol phosphate production in rat cerebellar granule cells with an IC50 of 13 nM. YM-230888 shows antinociceptive response in Streptozotocin (HY-13753)-induced hyperalgesia models. YM-230888 significantly reduces pain parameters in complete Freund's adjuvant (HY-153808)-induced arthritic pain models[1].
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