Pladienolide B
CAS No. : 445493-23-2
| Size | Price | Stock |
|---|---|---|
| 100μg | $150 | Get quote |
| 500μg | $480 | Get quote |
| 1mg | $768 | In-stock |
| 5mg | $1920 | In-stock |
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| 50 mg | Get quote | |
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| Cat. No. : | HY-16399 |
| M.Wt: | 536.70 |
| Formula: | C30H48O8 |
| Purity: | >98 % |
| Solubility: | DMSO : 1 mg/mL (ultrasonic;warming) |
Pladienolide B is a potent cancer cell growth inhibitor that targets the SF3B1 subunit of the spliceosome. Pladienolide B exerts antitumor activities mediated through the inhibition of pre-mRNA splicing. Pladienolide B induces apoptosis[1][2][3].
In Vitro: Pladienolide B (0.1-2 nM; 24-72 hours) inhibits human cervical carcinoma cells viability[3].
Pladienolide B (0.1-2 nM; 24-48 hours) reduces SF3b1 expression in human cervical carcinoma cells[3].
Pladienolide B induces (0.1-2 nM; 24 hours) cell cycle arrest and apoptosis[3].
In Vivo: Pladienolide B (2.5-10 mg/kg; i.v.; daily for 5 days) has strong antitumor activities[4].
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