ZM 449829
CAS No. : 4452-06-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $95 | In-stock |
| 10mg | $152 | In-stock |
| 25mg | $320 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-13450 |
| M.Wt: | 182.22 |
| Formula: | C13H10O |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
ZM 449829 is a potent, selective and ATP competitive inhibitor of JAK3, with a pIC50 of 6.8. ZM 449829 will be useful pharmacological tools for the investigation of the JAK3[1].
IC50 & Target:pIC50: 6.8 (JAK3)[1]
In Vitro: ZM 449829 (compound 22) is a very weak inhibitors of EGF-R (pIC50=5.0) , Jak1 (pIC50=4.7), and tyrosine kinases Lck and CDK4 (pIC50 <5.0)[1].
ZM449829 (1 μM; 30 minutes) blocks IL-2-induced STAT5 phosphorylation[2].
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