MK-0608
CAS No. : 443642-29-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $220 | In-stock |
| 10mg | $350 | In-stock |
| 50mg | $1100 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-10244 |
| M.Wt: | 280.28 |
| Formula: | C12H16N4O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
MK-0608 is a potent and orally bioavailable inhibitor of HCV replication in vitro with an EC50 of 0.3 μM (EC90=1.3 μM) in the subgenomic-replicon assay[1]. IC50 & Target:EC50: 0.3 μM (HCV replication)[1] In Vivo: Oral dosing of MK-0608 results in a potent antiviral effect. In preclinical pharmacokinetic experiments with rats, dogs, and rhesus monkeys, MK-0608 demonstrates good to excellent oral bioavailability (50 to 100%) and long plasma half-lives in dogs and rhesus macaques (9 and 14 h, respectively)[1].
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