Ligustilide
CAS No. : 4431-01-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $40 | In-stock |
| 5mg | $86 | In-stock |
| 10mg | $118 | In-stock |
| 25mg | $202 | In-stock |
| 50mg | $300 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-N0401 |
| M.Wt: | 190.24 |
| Formula: | C12H14O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Ligustilide is is a bioactive phthalide derivative isolated from Angelica sinensis and Chuanxiong. Ligustilide exhibits neuroprotective, anti-cancer, anti-inflammatory, and vasodilator effects[1][2][3]. In Vitro: Pretreatment with Ligustilide (1 μM, 5 μM, 15 μM) significantly improves cell viability. The apoptosis rate in glutamate-induced PC12 cells is 13.39%, and decreased in the presence of Ligustilide (1 μM, 5 μM, 15 μM) by 9.06%, 6.48%, 3.82%, separately. Extracellular accumulation of Ca2+ induced by glutamate are significantly reduced by Ligustilide. Pretreatment Ligustilide could decrease the release of cytochrome C from mitochondria, down-regulate Caspase-3 protein expression and up-regulate Bcl-2/Bax ratio, thereby protects PC12 cells from apoptosis[2].
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