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Erucin


CAS No. : 4430-36-8

4430-36-8
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Cat. No. : HY-121323
M.Wt: 161.29
Formula: C6H11NS2
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 4430-36-8 :

Erucin (ERU) is an isothiocyanate particularly abundant in arugula. Erucin shows anticancer, neuroprotective, and anti-inflammatory activities[1][2][3][4]. In Vitro:Erucin (ERU) (0-100 μM) releases H2S and inhibits cell viability in AsPC-1 cells in a concentration-dependent manner[1].
Erucin inhibits cell migration and altered the AsPC-1 cell cycle, reducing G0/G1 phase and increasing G2/M and S phases[1].
Erucin (30 μM, 72 h) induces AsPC-1 cell apoptosis and inhibits cell migration[1].
Erucin reduces levels of phosphorylated ERK1/2 in AsPC-1 cells[1].
Erucin (0-200 μM, 24 h) shows antiproliferative activity with an IC50 of 97.7 μM in A549 cells[2].
Erucin (0-50 μM, 24 h) induces the cleavage of PARP-1 at 50 μM, and increases p53 and p21 protein expression in A549 cells[2].
Erucin decreases LPS-induced production of NO, prostaglandin E2 (PGE2), TNF-α, IL-6 and IL-1β in RAW 264.7 cells[3].
Erucin decreases LPS-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 in RAW 264.7 cells[3].
Erucin inhibits LPS-induced activation of NFκB Signaling in RAW 264.7 cells[3]. In Vivo:Erucin (ERU) (0-300 nM) significantly inhibits TPA-induced edema formation[3].
Erucin (30 μmol/kg; i.p.; twice a week for 4 week) shows neuroprotective effects[4].

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