Metronidazole
CAS No. : 443-48-1
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| 500g | $49 | In-stock |
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| Cat. No. : | HY-B0318 |
| M.Wt: | 171.16 |
| Formula: | C6H9N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 35 mg/mL (ultrasonic;warming);H2O : 16.67 mg/mL (ultrasonic) |
Metronidazole is an orally active nitroimidazole antibiotic. Metronidazole can cross blood brain barrier. Metronidazole can be used for the research of anaerobic infections[1][2][3][4].
In Vitro:Metronidazole displays inhibitory activity towards anaerobic protozoa Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia, and Balantidium coli[1].
Metronidazole (4-8 μg/mL) inhibits anaerobic bacteria and shows good bactericidal activity[1].
Metronidazole (0.1 μg/mL-0.01 mg/mL; 12-96 h) induces granular formation and triggers apoptosis in Blastocystis sp[2].
In Vivo:Metronidazole (135 mg/kg/d; p.o.; 28 d) can cross the blood brain barrier, and exhibits neurotoxicity under long term administration in rats[3].
Metronidazole (1 g/L; p.o.; 4 weeks) results skeletal muscle atrophy and changes the expression of genes involved in the muscle peripheral circadian rhythm machinery and metabolic regulation[4].
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