Vipadenant
CAS No. : 442908-10-3
(Synonyms: BIIB-014; CEB-4520)
| Size | Price | Stock |
|---|---|---|
| 5mg | $75 | In-stock |
| 10mg | $115 | In-stock |
| 25mg | $198 | In-stock |
| 50mg | $295 | In-stock |
| 100mg | $440 | In-stock |
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| Cat. No. : | HY-10857 |
| M.Wt: | 321.34 |
| Formula: | C16H15N7O |
| Purity: | >98 % |
| Solubility: | DMSO : 31 mg/mL (ultrasonic;warming) |
Vipadenant (BIIB-014; CEB-4520) is an adenosine receptor antagonist, with Kis of 1.3 nM and 68 nM for A2A and A1, respectively. IC50 & Target: Ki: 1.3 nM (A2A), 68 nM (A1)[1], 1005 nM (A3)[2] In Vivo: Vipadenant (0.3-30 mg/kg) produces a dose-dependent reduction in catalepsy. Vipadenant (10 mg/kg) does not produce any statistically significant dyskinetic episodes in 6-OHDA-lesioned rats during a 19-day dosing regimen[1]. In the mouse and rat haloperidol-induced hypolocomotion models, vipadenant has a minimum effective dose of 0.1 and 1 mg/kg, respectively. Vipadenant (3 and 10 mg/kg, p.o.) is able to increase contralateral rotations in 6-OHDA lesioned rats[2].
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