(rac)-AG-205
CAS No. : 442656-02-2
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| Cat. No. : | HY-121012 |
| M.Wt: | 454.98 |
| Formula: | C22H23ClN6OS |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
(rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac)-AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway[1].
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