JW67
CAS No. : 442644-28-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $170 | In-stock |
| 25mg | $350 | In-stock |
| 50mg | $560 | In-stock |
| 100mg | $890 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-108442 |
| M.Wt: | 394.38 |
| Formula: | C21H18N2O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
JW67 inhibits the canonical Wnt signaling with an IC50 of 1.17μM[1]. JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth[1].
IC50 & Target: IC50: 1.17μM (Wnt signaling)[1]
In Vitro: JW67 (1 μM; 24 hours) increases concentration of AXIN2 and decreases the active form of β-catenin[1].
JW67 affects the expression of Wnt target genes and reduces cell growth of colon cancer cell lines[1].
JW67 shows a concentrationdependent reduction in proliferation with a GI50 value of 7.8 μM[1].
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