CK-666


CAS No. : 442633-00-3

442633-00-3
Price and Availability of CAS No. : 442633-00-3
Size Price Stock
5mg $99 In-stock
10mg $176 In-stock
25mg $415 In-stock
50mg $715 In-stock
100mg $950 In-stock
200 mg Get quote
500 mg Get quote
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Cat. No. : HY-16926
M.Wt: 296.34
Formula: C18H17FN2O
Purity: >98 %
Solubility: DMSO : 125 mg/mL (ultrasonic)
Introduction of 442633-00-3 :

CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor (IC50=12 μM). CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation[1][2]. IC50 & Target: Arp2/3 complex[1] In Vitro: CK-666 (100 μM) significantly reduces the number of filopodia on the cell surface of treated trabecular meshwork (TM) cells as well as reduces the length of those filopodia that are present[3].

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