LB80317

LB80317 is an active metabolite of LB80380 and suppresses the DNA synthesis of HBV with an EC₅₀ of 0.5 μM. LB80317 has antiviral effect and has the potential for chronic hepatitis B treatment^[1][2]. IC50 & Target: EC50: 0.5 μM (DNA synthesis of HBV)^[2] In Vitro: After phosphorylation to di- and triphosphate forms, LB80317 is incorporated into the viral DNA inside the nucleocapsid, which inhibits further DNA synthesis. In in vitro studies using cell line models, the drug concentrations causing 50% reduction in HBV DNA produced (EC₅₀) is 0.5 μM for LB80317^[2]. In Vivo: Forty percent of the amount of LB80331/LB80317 in the mouse liver is detected as the phosphorylated form. LB80380 is rapidly absorbed and converted to LB80331. LB80317 has a long half-life at steady-state (T_1/2=8.3-9.9 hours)^[1].