WAY-200070


CAS No. : 440122-66-7

440122-66-7
Price and Availability of CAS No. : 440122-66-7
Size Price Stock
5mg $106 In-stock
10mg $145 In-stock
25mg $317 In-stock
50mg $568 In-stock
100mg $1016 In-stock
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Cat. No. : HY-101271
M.Wt: 306.11
Formula: C13H8BrNO3
Purity: >98 %
Solubility: DMSO : ≥ 31 mg/mL (101.27 mM)
Introduction of 440122-66-7 :

WAY-200070 is a selective estrogen receptor β (ERRβ) agonist with an IC50 of 2.3 nM. IC50 & Target: IC50: 2.3 nM (ERRβ), 155 nM (ERRα)[1] In Vivo: Administration of WAY-200070 (30 mg/kg s.c.) causes nuclear translocation of ERRβ receptors in WT mice. Administration of WAY-200070 (30 mg/kg s.c.) produces a delayed 50% increase in dopamine in the striatum of wild type mice. WAY-200070 (30 mg/kg s.c.) reduces immobility time in the mouse tail suspension test indicating an antidepressant-like effect[1]. In gonadally intact male and female mice WAY-200070 increases agonistic behaviors such as pushing down and aggressive grooming, while leaving attacks unaffected[2]. Ovariectomized (ovx) mice treated with PPT fail to learn the socially acquired preference, while WAY-200070-treated ovx mice shows a two-fold prolonged preference for the food eaten by their demonstrator[3]. WAY-200070, shows significantly decreased anxiety-like behaviors in both the open-field and elevated plus maze and significantly less depressive-like behaviors in the forced swim test[4].

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