Aβ aggregation-IN-6
CAS No. : 439932-74-8
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| Cat. No. : | HY-123745 |
| M.Wt: | 391.33 |
| Formula: | C15H16Cl2N2O2S2 |
| Purity: | >98 % |
| Solubility: |
Aβ aggregation-IN-6 (compound 4) is an Aβ aggregation inhibitor with ~60-70% inhibition of Aβ17-40 aggregation. Aβ aggregation-IN-6 stabilizes Aβ dimer assembly, binds to Aβ steric-zipper assembly, and interferes with aggregation into higher-order toxic species. Aβ aggregation-IN-6 can be used for the research of alzheimer's disease[1].
In Vitro:Aβ aggregation-IN-6 (compound 4) stabilizes the Aβ dimer assembly via multiple polar and nonpolar interactions, with a CDOCKER interaction energy of -18.93 kcal/mol, to inhibit further Aβ aggregation[1].
Aβ aggregation-IN-6 (compound 4) binds to the Aβ steric-zipper assembly via multiple favorable interactions, with a CDOCKER interaction energy of -30.48 kcal/mol, to stabilize the assembly and reduce Aβ aggregate cytotoxicity[1].
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