Pro-xylane

Pro-xylane (Hydroxypropyl tetrahydropyrantriol) is a bioactive C-glycoside that targets the biosynthesis pathway of glycosaminoglycans/mucopolysaccharides (GAGs) in the skin matrix and can be absorbed transdermally. Pro-xylane stimulates the biosynthesis of GAGs in fibroblasts, enhances the structural stability of the skin extracellular matrix, improves skin elasticity and moisturizing ability, and delays wrinkle formation. Pro-xylane can effectively promote the synthesis of collagen fibers and hyaluronic acid in the dermis. Pro-xylane is used in the field of anti-aging cosmetics to improve skin hydration and elasticity. Pro-xylane is eco-friendly and biodegradable^[1][2][3][4]. In Vitro: Pro-xylane (0.3-3.0 mM; 96 h) stimulates the synthesis of GAGs in human fibroblasts^[1].
Pro-xylane is the catalytic substrate of the recombinant carbonyl reductase R129E/D210F, whose key activity lies in the high stereoselectivity of the β-S configuration. Under the catalysis of R129E/D210F, Pro-xylane produces >99% β,S-diastereomeric excess^[2].
Pro-xylane has the ability of efficient asymmetric synthesis^[3]. In Vivo: Liposome gel loaded with Pro-xylane intermediate has a promoting effect on the recovery of chronic wounds. In a rat chronic wound model, Pro-xylane intermediate was encapsulated with liposomes to obtain PXYI liposome gel (PXYI-LG). PXYI-LG can promote the healing of chronic wounds in rats and shorten the healing time^[4].