Protriptyline
CAS No. : 438-60-8
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| Cat. No. : | HY-B0949A |
| M.Wt: | 263.38 |
| Formula: | C19H21N |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Protriptyline is a potent tricyclic antidepressant (TCA). Protriptyline inhibits AChE activity with an IC50 value of 0.06 mM and inhibits Aβ self-assembly. Protriptyline can be used for the study of depression and Alzheimers disease[1][2][3]. In Vitro:Protriptyline (0-70 μM; 24 hours; PC3 cells) causes cytotoxicity in PC3 cells[2]. In Vivo:Protriptyline (10 mg/kg; i.p.; for 21 days; rat model of AD) improves spatial learning and retention memory in STZ treated rats[3].
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