Mono-(2-ethylhexyl) phthalate
CAS No. : 4376-20-9
(Synonyms: MEHP; Phthalic acid mono-2-ethylhexyl ester)
| Size | Price | Stock |
|---|---|---|
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| 5g | $86 | In-stock |
| 10g | $157 | In-stock |
| 25g | $390 | In-stock |
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| Cat. No. : | HY-W018392 |
| M.Wt: | 278.35 |
| Formula: | C16H22O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Mono-(2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP). Mono-(2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD)[1].
In Vitro:Mono-(2-ethylhexyl) phthalate (0-100 μM, 48 h) can promote lipid accumulation in HepG2 cells[1].
Mono-(2-ethylhexyl) phthalate (0-100 μM, 24-48 h) increases the TG level in HepG2 cells in a dose-dependent manner[1].
In Vivo:Mono-(2-ethylhexyl) phthalate (0.1-1 mL/kg, p.o., daily, 3 days) causes fetal malformations and reduces live fetuses in pregnant mice[2].
Mono-(2-ethylhexyl) phthalate (25-50 mg/kg, i.p., once time) induces a significantly high incidence of somatic mutations in the coat hair of offspring of mice[2].
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