Xanthinol Nicotinate
CAS No. : 437-74-1
(Synonyms: Xanthinol Niacinate)
| Size | Price | Stock |
|---|---|---|
| 50mg | $60 | In-stock |
| 100mg | $105 | In-stock |
| 250mg | $210 | In-stock |
| 500mg | $365 | In-stock |
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| Cat. No. : | HY-B1815 |
| M.Wt: | 434.45 |
| Formula: | C19H26N6O6 |
| Purity: | >98 % |
| Solubility: | H2O : 250 mg/mL (ultrasonic) |
Xanthinol Nicotinate (Xanthinol Niacinate), a vasodilator, can act directly on the smooth muscle of small arteries and capillaries. Xanthinol Nicotinate expands blood vessels, improves blood rheology and reduces peripheral vascular resistance[1][2].
In Vitro: Xanthinol Nicotinate (Xanthinol Niacinate; 2.76-276 µM; for 24 hours) inhibits HUASMC proliferation in a dose-dependent manner[2].
Xanthinol Nicotinate (2.76-276 µM; for 24 hours) dose-dependently decreases the PDGFR mRNA and PDGFR-β levels on the cell membranes of HUASMCs[2].
In Vivo: Xanthinol Nicotinate (Xanthinol Niacinate; 75 mg/kg; IP) rapidly and transiently modifies tumor pO2 and the maximal pO2 values are obtained 10 to 30 minutes after Xanthinol Nicotinate administration[1].
Xanthinol Nicotinate is able to radiosensitize the tumors when applying 10 Gy of X-Rays during the reoxygenation of the tumors (enhancement in radiation response of 1.4)[1].
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