MRS2365
CAS No. : 436847-09-5
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| Cat. No. : | HY-108656 |
| M.Wt: | 483.33 |
| Formula: | C13H19N5O9P2S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
MRS2365 is a potent and selective P2Y1 receptor (EC50=0.4 nM) /[35S]GTPγS binding/β-arrestin 2 recruitment agonist with an EC50 of 0.4 nM. MRS2365 relieves mechanical allodynia and increases mechanical sensitivity. MRS2365 shows little agonist or antagonist activity at the P2Y12 or P2Y13 receptors[1][2][3][4].
IC50 & Target:[35S]GTPγS binding; β-arrestin 2 recruitment[4]
In Vitro:MRS2365 (1 µM or 3 µM; 2 min) weakens adenosine diphosphate (ADP)-induced platelet aggregation[2].
In Vivo:MRS2365 (0.03-0.3 mg/kg; i.p.; single dose) significantly alleviates the mechanical allodynia in the male wistar rats neuropathy (Seltzer) model with dose-dependent manner[3].
MRS2365 (0.1-2 mg/kg; i.p.; single dose) increases the paw withdrawal threshold (PWT) in male wistar rats with neuropathic pain model[3].
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