N6-(2-Hydroxyethyl)adenosine

N6-(2-Hydroxyethyl)adenosine is a purine nucleoside analog. N6-(2-Hydroxyethyl)adenosine inhibits NF-κB/Smad signaling pathway, exhibits anti-hyperglycemia, antioxidant, antitumor and anti-inflammatory and insecticidal activities. N6-(2-Hydroxyethyl)adenosine is orally active^{[1][2][3][4][5]}. In Vitro:N6-(2-Hydroxyethyl)adenosine (5-20 µg/mL, 24 h) reduces the expression of LPS (HY0D1056)-induced TNF-α and IL-1β, increases the IL-10 secretion in RAW 264.7 cell^[3].
N6-(2-Hydroxyethyl)adenosine (5-20 µg/mL, 24 h) reduces TGF-β1-induced expression of collagen I, α-SMA and fibronectin in NRK-49F cell, exhibits anti-fibrosis effect^[3].
N6-(2-Hydroxyethyl)adenosine (0-300 µM, 24-72 h) induces the generation of ROS, decreases mitochondrial membrane potential, exhibits cytotoxicity in cancer cells SGC-7901 and AGS, and induces apoptosis and autophagy^[4].
N6-(2-Hydroxyethyl)adenosine (1 mg/mL, 60 h) exhibits insecticidal activity against Plutella xylostella^[5].
In Vivo:N6-(2-Hydroxyethyl)adenosine (20-40 mg/kg, ip, once daily for 6 weeks) reduces the blood glucose level and diabetes-induced kidney damage, increases the activities of antioxidant enzymes (such as SOD, catalase CAT and GSH) in renal tissue, reduces the level of malondialdehyde (MDA), exhibits anti-inflammatory and antioxidant activities, and ameliorates Alloxan (HY-W017227)-induced diabetes in rats models^[2].
N6-(2-Hydroxyethyl)adenosine (75-150 mg/kg, po, once daily for 19 days) exhibits antitumor effect in SGC-7901 xenograft mouse models^[4].