4E2RCat
CAS No. : 432499-63-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $25 | In-stock |
| 10mg | $45 | In-stock |
| 25mg | $103 | In-stock |
| 50mg | $176 | In-stock |
| 100mg | $300 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-100733 |
| M.Wt: | 455.93 |
| Formula: | C22H14ClNO4S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 23.33 mg/mL (ultrasonic) |
4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM. IC50 & Target: IC50: 13.5 μM (eIF4E-eIF4G)[1] In Vitro: 4E2RCat prevents the interaction between eIF4E (the cap-binding protein) and eIF4G (a large scaffolding protein), inhibiting cap-dependent translation. It significantly decreases human coronavirus 229E (HCoV-229E) replication, reducing the percentage of infected cells and intra- and extracellular infectious virus titers. 4E2RCat inhibits cap-dependent translation in a dose-dependent manner. 4E2RCat inhibits cap-dependent FF translation but not EMCV IRES-driven Ren translation. 4E2RCat inhibits coronavirus replication in a dose- and time-dependent manner[1]. In Vivo: 4E2RCat inhibits protein synthesis in vivo and it is not a consequence of increased cell death[1].
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