Midodrine (hydrochloride)
CAS No. : 43218-56-0
(Synonyms: (±)-Midodrine (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $160 | In-stock |
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| Cat. No. : | HY-12749A |
| M.Wt: | 290.74 |
| Formula: | C12H19ClN2O4 |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic) |
Midodrine hydrochloride ((±)-Midodrine hydrochloride) is a selective and orally active adrenergic α1-receptor agonist. Midodrine hydrochloride can strengthen vascular contraction. Midodrine hydrochloride can be used for the researches of cardiovascular disease, such as orthostatic hypotension[1][2][3].
In Vitro:Midodrine hydrochloride (30 μM, 0-24 h) increases p-AMPK and PPARδ expression in C2C12, HL1 and HepG2 cells[3].
Midodrine hydrochloride (30 μM, 0-1 min) increases Ca2+ in C2C12, HL1 and HepG2 cells[3].
Midodrine hydrochloride (30 μM) increases maximal mitochondrial oxidative phosphorylation and ATP content in C2C12 cells[3].
Midodrine hydrochloride (30-100 μM) reduces cellular lipid content in 3T3-L1 cells[3].
In Vivo:Midodrine hydrochloride (20 mg/kg, i.p., 30 mins before Paf) reduces platelet-activating factor (Paf)-induced death in mice[1].
Midodrine hydrochloride (5 mg/kg, i.g.) shows anti-hypotensive effects in orthostatic hypotension rats models[2].
Midodrine hydrochloride (0.3 mg/kg, p.o., 4 weeks.) relieves hypertension in spontaneously hypertensive rats models[3].
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