NPPM 6748-481
CAS No. : 432020-20-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $130 | In-stock |
| 50mg | $190 | In-stock |
| 100mg | $280 | In-stock |
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| Cat. No. : | HY-15784 |
| M.Wt: | 363.77 |
| Formula: | C17H15ClFN3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
NPPM 6748-481 is a potent and selective yeast Sec14 inhibitor with a yeast Sec14 IC50 of 211 nM. NPPM 6748-481 disrupts membrane trafficking, impairing trans-Golgi network-endosomal transport and endocytic transport. NPPM 6748-481 impairs Snc1 v-SNARE recycling, secretory invertase trafficking, and vacuolar carboxypeptidase Y processing. NPPM 6748-481 can be used for research on yeast infection[1].
In Vitro:NPPM 6748-481 (30 min) potently and selectively inhibits purified yeast Sec14-catalyzed [3H]PtdIns transfer in vitro with an IC50 of 211 nM, and does not inhibit related yeast Sfh1-Sfh5 PITPs at concentrations up to 40 μM[1].
NPPM 6748-481 (10-16 h) inhibits growth of WT haploid Saccharomyces cerevisiae with an IC50 of 2.87 μM, and sensitivity to the compound directly correlates with cellular Sec14 levels[1].
NPPM 6748-481 (30 min) has drastically reduced inhibitory sensitivity against purified yeast Sec14 with mutations in specific residues (Y111, Y151, S201, S173) in vitro, with Sec14S173C showing >736-fold resistance[1].
NPPM 6748-481 (20-40 μM; 48 h) does not inhibit growth of Saccharomyces cerevisiae expressing NPPM-resistant Sec14S173C, and "bypass Sec14" cki1Δ and kes1Δ mutants are also resistant to the compound, confirming Sec14 as the sole essential cellular target[1].
NPPM 6748-481 (20 μM; 3 h) selectively disrupts TGN-endosomal PtdIns-4-P pools in WT Saccharomyces cerevisiae without affecting plasma membrane PtdIns-4-P pools, phenocopying genetic Sec14 inactivation[1].
NPPM 6748-481 (20 μM) does not interfere with Sfh4-dependent PtdSer decarboxylation to PtdEtn in Saccharomyces cerevisiae psd1Δ mutants, demonstrating selective inhibition of Sec14-dependent versus Sfh4-dependent PtdIns-4-P signaling in TGN-endosomes[1].
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