Skp2 Inhibitor C1


CAS No. : 432001-69-9

(Synonyms: SKPin C1)

432001-69-9
Price and Availability of CAS No. : 432001-69-9
Size Price Stock
5mg $60 In-stock
10mg $98 In-stock
25mg $211 In-stock
50mg $350 In-stock
100mg $515 In-stock
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Cat. No. : HY-16661
M.Wt: 465.34
Formula: C18H13BrN2O4S2
Purity: >98 %
Solubility: DMSO : 20.83 mg/mL (ultrasonic)
Introduction of 432001-69-9 :

Skp2 Inhibitor C1 (SKPin C1) is an S-phase kinase-related protein 2 (Skp2) inhibitor with an inhibitory effect on metastatic melanoma cells. Skp2 Inhibitor C1 slows the cell cycle, inhibits cell proliferation, and triggers apoptosis[1]. In Vitro:Skp2 Inhibitor C1 (10-50 μM; 12 hr) decreases the viability of THP-1, U266 and RPMI 8226 cells[1].
Skp2 Inhibitor C1 (25 μM) increases p27 protein levels in U266 and RPMI 8226 cells by inhibiting ubiquitination[1].
Skp2 Inhibitor C1 (25 μM) inhibits cell cycle of U266 and RPMI 8226 cells[1].
In Vivo:Skp2 Inhibitor C1 (5 mg/kg and 10 mg/kg; 3 times within 24 h: 24, 5, and 1 h before the test) shows the antidepressant-like effect in mouse models following chronic treatment by using the tail suspension test (TST), forced swimming test (FST), and social interaction test (SIT)[2].

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