PPI-2458
CAS No. : 431077-35-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $625 | In-stock |
| 10mg | $1000 | In-stock |
| 25mg | $2000 | In-stock |
| 50mg | $3200 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-13731 |
| M.Wt: | 424.53 |
| Formula: | C22H36N2O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
PPI-2458 is a potent, orally active, selective and irreversible inhibitor of methionine aminopeptidase-2 (MetAP-2). PPI-2458 can be used for arthritis and lymphoma research[1][2].
In Vitro: PPI-2458 potently inhibits HUVEC proliferation with a GI50 of 0.2 nM and a maximum inhibition of >95% at 1 nM[1].
PPI-2458 (0-100 nM, 6 days) inhibits proliferation and MetAP-2 in SU-DHL-16 cells[2].
In Vivo: PPI-2458 (0-50 mg/kg, Orally, qod) reverses joint swelling and inflammation in the PG-PS (25 mg/kg, i.p.)-induced arthritis model[1].
PPI-2458 (0-3 mg/kg, Nasogastric intubation, qod) shows a decrease in germinal center lymphocytes in experimentally naive cynomolgus monkeys[2].
PPI-2458 (0-100 mg/kg, Orally, qod) significantly suppresses tumor growth in a dose-dependent manner in severe combined immunodeficient mice with SR tumor xenografts [2].
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