Y16
CAS No. : 429653-73-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $40 | In-stock |
| 5mg | $84 | In-stock |
| 10mg | $144 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-12649 |
| M.Wt: | 384.43 |
| Formula: | C24H20N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
Y16 is a specific inhibitor of Leukemia-associated Rho guanine nucleotide exchange factor (LARG) with a Kd value of 76 nM. Y16 is active in blocking the interaction of LARG and related G-protein-coupled Rho GEFs with RhoA. Y16 shows no detectable effect on other diffuse B-cell lymphoma (Dbl) family Rho GEFs, Rho effectors, or a RhoGAP[1].
IC50 & Target: Kd: 76 nM (LARG)[1]
In Vitro: Y16 (10-30 μΜ; 24 hours; NIH 3T3 cells) could inhibit RhoA-GTP formation induced by serum dose dependently and is specific for RhoA[1].
Y16 (10-30 μΜ; 24 hours; NIH 3T3 cells) efficiently inhibits serum or SDF-1α-induced phospho-MLC and phospho-FAK formation, which are downstream of RhoA[1].
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