Nabumetone
CAS No. : 42924-53-8
(Synonyms: BRL14777)
| Size | Price | Stock |
|---|---|---|
| 1g | $33 | In-stock |
| 5g | $73 | In-stock |
| 25g | $245 | In-stock |
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| Cat. No. : | HY-B0559 |
| M.Wt: | 228.29 |
| Formula: | C15H16O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL;H2O : < 0.1 mg/mL |
Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the proagent of the active metaboliteα-Demethylnaproxen (HY-W086896). Nabumetone can inhibit cancer cells proliferation and relieve gastric ulcers[1][2][3].
IC50 & Target:COX-2[1]
In Vitro:Nabumetone (50-500 μM, 48 h) dose-dependently inhibits the proliferation of K-562 and Meg-01 cells, but shows no obvious apoptotic effect[1].
Nabumetone (50-100 μM) potentiates the apoptotic effect of ADR (HY-15142) and reduces Bcl-2 expression in the K-562 cells[1].
In Vivo:Nabumetone (79 mg/kg, p.o.) inhibits paw oedema and paw exudate PGE in rats[2].
Nabumetone does not induce gastric damage and causes only 57% inhibition of gastric mucosal 6-keto-PGF1α production in rats[2].
Nabumetone (25, 50, 100 mg/kg, i.p.) dose-dependently inhibits the increase of Diethyldithiocarbamate-induced mucus secretion and stimulates stress-induced mucus secretion in rats[3].
Nabumetone (25 mg/kg, i.p.) significantly suppresses stress-induced ulcer index in rats[3].
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