14-Deoxy-11,12-didehydroandrographolide
CAS No. : 42895-58-9
(Synonyms: 14-dehydro Andrographolide; AP10)
| Size | Price | Stock |
|---|---|---|
| 1mg | $79 | In-stock |
| 5mg | $200 | In-stock |
| 10mg | $289 | In-stock |
| 25mg | $489 | In-stock |
| 50mg | $715 | In-stock |
| 100mg | $987 | In-stock |
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| Cat. No. : | HY-N1490 |
| M.Wt: | 332.43 |
| Formula: | C20H28O4 |
| Purity: | >98 % |
| Solubility: | DMF : 100 mg/mL (ultrasonic);DMSO : 110 mg/mL (ultrasonic) |
14-Deoxy-11,12-didehydroandrographolide is an analogue of Andrographolide. 14-Deoxy-11,12-didehydroandrographolide inhibits NF-κB activation. IC50 & Target: NF-κB[1] In Vitro: 14-deoxy-11,12-didehydroandrographolide, a naturally occurring noncytotoxic analogue of Andrographolide, effectively reduces Ovalbumin (OVA)-induced inflammatory cell recruitment into bronchoalveolar lavage (BAL) fluid, IL-4, IL-5, IL-13, and eotaxin production, serum IgE synthesis, pulmonary eosinophilia, mucus hypersecretion, mast cell degranulation, and airway hyper-responsiveness (AHR) in a mouse asthma model, probably via inhibition of NF-κB activity[1]. In Vivo: 14-deoxy-11,12-didehydroandrographolide (1 mg/kg) dramatically reduces resistance (Rl) and restores Cdyn in OVA-challenged mice in response to methacholine[1].
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