PNU-176798
CAS No. : 428861-91-0
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| Cat. No. : | HY-100306 |
| M.Wt: | 360.36 |
| Formula: | C16H13FN4O3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
PNU-176798 is an antimicrobial agent, targeting protein synthesis in a wide spectrum of gram-positive and anaerobic bacteria. IC50 & Target: Bacterial[1] In Vitro: PNU-176798 is an antimicrobial agent, with a minimum inhibitory concentration (MIC) of 1.4 μM for E. coli. PNU-176798 inhibits fMet-tRNA binding to the 70S ribosomes, with an IC50 of 32 μM. PNU-176798 also blocks translation, 70S initiation with IC50s of 0.53, and 32 μM, respectively. PNU-176798 inhibits peptidyl transferase (IC50, 40 μM), and the inhibition is more pronounced in the presence of elongation factor P (EF-P). PNU-176798 markedly inhibits the EF-G-mediated translocation of fMet-tRNA (IC50, 8 μM)[1].
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