Midodrine
CAS No. : 42794-76-3
(Synonyms: (±)-Midodrin)
| Size | Price | Stock |
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| 10mg | $80 | In-stock |
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| Cat. No. : | HY-12749 |
| M.Wt: | 254.28 |
| Formula: | C12H18N2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
Midodrine is a selective and orally active adrenergic α1-receptor agonist. Midodrine can strengthen vascular contraction. Midodrine can be used for the researches of cardiovascular disease, such as orthostatic hypotension[1][2][3].
In Vitro:Midodrine (30 μM, 0-24 h) increases p-AMPK and PPARδ expression in C2C12, HL1 and HepG2 cells[3].
Midodrine (30 μM, 0-1 min) increases Ca2+ in C2C12, HL1 and HepG2 cells[3].
Midodrine (30 μM) increases maximal mitochondrial oxidative phosphorylation and ATP content in C2C12 cells[3].
Midodrine (30-100 μM) reduces cellular lipid content in 3T3-L1 cells[3].
In Vivo:Midodrine (20 mg/kg, i.p., 30 mins before Paf) reduces platelet-activating factor (Paf)-induced death in mice[1].
Midodrine (5 mg/kg, i.g.) shows anti-hypotensive effects in orthostatic hypotension rats models[2].
Midodrine (0.3 mg/kg, p.o., 4 weeks.) relieves hypertension in spontaneously hypertensive rats models[3].
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