Cyproterone acetate
CAS No. : 427-51-0
| Size | Price | Stock |
|---|---|---|
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| 500mg | $120 | In-stock |
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| Cat. No. : | HY-13604 |
| M.Wt: | 416.94 |
| Formula: | C24H29ClO4 |
| Purity: | >98 % |
| Solubility: | Ethanol : 20 mg/mL (ultrasonic);DMSO : 33.33 mg/mL (ultrasonic);H2O : < 0.1 mg/mL |
Cyproterone acetate is an anti-androgen (IC50=7.1 nM) and progestogen synthetic steroid. Cyproterone acetate has affinity with progesteron and with glucocorticoidal receptors[1][2].
In Vitro: Cyproterone acetate is a partial agonist, showing agonism for the AR, with EC50 of 4.0 μM, at relatively high concentrations[1].
Cyproterone acetate enhances TRAIL-induced androgen-independent prostate cancer cell apoptosis via up-regulation of death receptor 5[3].
Cyproterone acetate pretreatment (0,1,10, or 50 μM; 24 hours; subsequently exposed to cadmium for an additional 24 hours) resulted in a clear decrease in the sensitivity to cadmium in rat liver epithelial cell line[4].
In Vivo: Adult male C57 BL/6J mice injected with 0.08 mg/g of cyproterone acetate showed an increase in cellular lipid content in the zona fasciculata and zona retjculans of the adrenal cortex[5].
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