NVP-ABE171


CAS No. : 426268-06-6

426268-06-6
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Cat. No. : HY-114052
M.Wt: 368.34
Formula: C21H12N4O3
Purity: >98 %
Solubility:
Introduction of 426268-06-6 :

NVP-ABE171 is an efficient, long-lasting and orally active PDE4 inhibitor with IC50 values for PDE4D, PDE4B, PDE4A and PDE4C of 1.5, 34, 602 and 1230 nM respectively. NVP-ABE171 enhances the cAMP accumulation induced by isoproterenol, inhibits the oxidative burst of eosinophils and the release of inflammatory cytokines from T cells and monocytes. NVP-ABE171 exhibits potent anti-inflammatory activity in animal models of asthma and pulmonary inflammation. NVP-ABE171 can be used for research on asthma and chronic obstructive pulmonary disease[1].

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