CASIN
CAS No. : 425399-05-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $92 | In-stock |
| 10mg | $158 | In-stock |
| 25mg | $317 | In-stock |
| 50mg | $581 | In-stock |
| 100mg | $950 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12874 |
| M.Wt: | 306.40 |
| Formula: | C20H22N2O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 31 mg/mL |
CASIN is a selective GTPase Cdc42 inhibitor with an IC50 of 2 uM. CASIN can be used for the research of cancer[1][2]. IC50 & Target: IC50: 2 μM (GTPase Cdc42)[1] In Vitro: CASIN (0-10 μM; 3 d) inhibits the growth of AMO-1, ARH-77, IM-9 , JJN-3, L-363, MOLP-8 and RPMI-8226/S cells[1]. CASIN (0-10 μM; 16 h) inhibits melphalan induced FANCD2 mono-ubiquitination in LR5 cells but shows no effect to S cells[1]. CASIN (5 μM; 2 d) increases cell apoptosis of bortezomib-resistant MM patient cells[1]. In Vivo: CASIN (20 mg/kg; i.p. 2 times a day) prolongs lifetime of mice with busulfan injection[1].
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