Nimustine
CAS No. : 42471-28-3
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| Cat. No. : | HY-13703 |
| M.Wt: | 272.69 |
| Formula: | C9H13ClN6O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Nimustine is an alkylating agent, which induces DNA double-strand breaks (DSBs) and inter-strand crosslinks (ICLs), thereby activating the DNA damage response (DDR) signaling pathway. Nimustine activates p38 MAPK/JNK signaling pathway, and exhibits antitumor activity[1][2].
In Vitro:Nimustine (50 μM, 72 h) activates caspase and AP-1, upregulates the expression of bim, promotes the phosphorylation of c-Jun, and induces apoptosis in cell LN-229[1].
In Vivo:Nimustine (15-30 mg/kg, iv, every two weeks for 2 doses, or once weekly for 4 doses) inhibits the tumor growth when combined with radiotherapy, exhibits toxicity in mice[2].
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