Diltiazem
CAS No. : 42399-41-7
| Size | Price | Stock |
|---|---|---|
| 100mg | $50 | In-stock |
| 500mg | $120 | In-stock |
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| Cat. No. : | HY-B0632 |
| M.Wt: | 414.52 |
| Formula: | C22H26N2O4S |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : 50 mg/mL (ultrasonic) |
Diltiazem is an orally active L-type Ca2+ channel blocker. Diltiazem shows antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris[1][2][3].
IC50 & Target:L-type Ca2+ channel[1]
In Vitro: Diltiazem (200 µM) elicits a use-dependent blockade that proceeded within a relatively small number of pulses[1].
Diltiazem reduces Ca2+ influx by accelerating inactivation during action potentials, and that the use-dependent blockade is due to increases in the number of channels in a sustained closed state[1].
In Vivo: Diltiazem (100 mg/kg; p.o.; for 4 weeks) prevents aortic aneurysm formation in a blood pressure-independent manner[3].
Diltiazem limits aortic aneurysm formation in mice by a blood pressure-independent anti-inflammatory effect on monocytic cells[3].
Diltiazem (2 mg/kg; i.v.) exhibits T1/2 of 61.2 min, CLel of 3.2 mL/min in rats[4].
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