Parmodulin 2
CAS No. : 423735-93-7
(Synonyms: ML161)
| Size | Price | Stock |
|---|---|---|
| 1mg | $36 | In-stock |
| 5mg | $77 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $195 | In-stock |
| 50mg | $310 | In-stock |
| 100mg | $490 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-13965 |
| M.Wt: | 361.23 |
| Formula: | C17H17BrN2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Parmodulin 2 (ML161) is an allosteric inhibitor of protease-activated receptor 1 (PAR1) with an IC50 of 0.26 μM[1]. Parmodulin 2 is a potent and non-competitive inhibitor of SFLLRN-induced P-selectin expression leading to inhibition of platelet aggregation in vitro and platelet thrombus formation in vivo[2].
IC50 & Target: IC50: 0.26 μM (PAR1)[1]
In Vitro: Parmodulin 2 (ML161; 10 µM; for 30 minutes) inhibits proinflammatory signaling in endothelial HUVECs cells[3].
In Vivo: Parmodulin 2 (ML161; 5 mg/kg; IV) significantly inhibits platelet thrombus formation, with a 73% inhibition in AUC (area under the curve)[2].
Parmodulin 2 inhibits platelet thrombus formation in vivo, and it does not prolong bleeding time. Parmodulin 2 selectively inhibits platelet aggregation through Par1 and the α2A-adrenergic receptor[2].
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