SC-57461A

SC-57461A is a potent, orally active, nonpeptide, and selective inhibitor of Leukotriene A4 (LTA4) hydrolase with IC₅₀s of 2.5 nM, 3 nM, and 23 nM for recombinant human, mouse, and rat LTA4 hydrolase, respectively^[1]. In Vitro: SC-57461A inhibits ionophore-stimulated LTB4 production in whole blood with IC₅₀s of 49, 166, and 466 nM in human mouse and rat, respectively^[1]. SC-57461A demonstrates excellent potency against LTA4 hydrolase (IC₅₀=2.5 nM) and in whole cells (IC₅₀=49 nM)^{[2]< In Vivo: SC-57461A also shows excellent potency in the mouse ex vivo assay, inhibiting the production of LTB4 with an ED₅₀=0.2 mg/kg and an ED₉₀=1 mg/kg. SC-57461A also inhibits the production of LTB4 in the rat peritoneal model with an ED₅₀=1 mg/kg[2]. SC-57461A is a potent, selective, and competitive inhibitor of LTA4 hydrolase with excellent activity in whole animals. SC-57461A demonstrates good oral activity in both the mouse and the rat[3].}