Perflubron

Perflubron (Perfluorooctyl bromide) is a contrast medium for magnetic resonance imaging and sonography. Perflubron inhibits chemokine expression and NF-κB activation. Perflubron can be emulsified with egg phospholipids (EYP) and shows exceptionally fast excretion characteristics. Perflubron has anti-inflammatory, antiviral and cytoprotective effects^{[1][2][3][4][5][6][7]}. In Vitro:Perflubron (40-48 h) attenuates neutrophil adhesion to activated endothelial cells (HUVECs) in vitro^[2].
Perflubron (200 μL, 3 days) protects against hyperoxia-induced airway epithelial cell (Calu-3) injury by promoting cellular integrity as well as cytologic modifications^[3].
Perflubron (40 min-4 h) stimulates mucin secretion in the tracheal segments of adult ferrets^[4].
In Vivo:Perflubron (50 μL, intranasal delivery, 24 h before mice are killed) reduces lung inflammation in respiratory syncytial virus infection mice by inhibiting chemokine expression and NF-κB activation^[5].
Perflubron (10 mL/kg, instillation, instilled over approximately 1 min) enhances adenovirus-mediated gene expression in lungs of transgenic mice with chronic alveolar filling^[6].
Perflubron (39.4-46.6 mL/kg, instillation, instillation times of 17-28 minutes) increases BAL fluid total cell count and β-galactosidase activity in rhesus macaques^[7].