Hesperadin
CAS No. : 422513-13-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $62 | In-stock |
| 10mg | $92 | In-stock |
| 25mg | $160 | In-stock |
| 50mg | $250 | In-stock |
| 100mg | $390 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-12054 |
| M.Wt: | 516.65 |
| Formula: | C29H32N4O3S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Hesperadin is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin inhibits Aurora B with an IC50 of 250 nM. Hesperadin inhibits the growth of Trypanosoma brucei by blocking nuclear division and cytokinesis. Hesperadin also is a broad-spectrum influenza antiviral[1][2][3].
IC50 & Target:IC50: 250 nM (Aurora B)[1]
In Vitro: Hesperadin (10-100 nM) inhibits the Aurora kinase-1 (TbAUK1)-mediated phosphoryation of trypanosome histone H3 (TbH3) in a dose dependent manner, with an IC50 of 40 nM[1].
Hesperadin (0.01-10 μM; 24 or 48 hours) inhibits growth of bloodstream forms (BF) and procyclic forms (PF) cultures[1].
Hesperadin (100-200 nM; 24-72 hours) alters cell morphology and inhibits cell cycle progression similar to the RNAi knockdown of TbAUK1[1].
In Vivo: Hesperadin (20 mg/kg/d; i.v.) prolongs the survival of xenograft mice via synergistic effect with temozolomide (TMZ)[2].
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