PU-20F
CAS No. : 422508-29-0
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| Cat. No. : | HY-121706 |
| M.Wt: | 417.44 |
| Formula: | C20H24FN5O4 |
| Purity: | >98 % |
| Solubility: |
PU-20F (compound 59) is a Hsp90 inhibitor with an EC50 of 6.8 μM. PU-20F competes with Geldanamycin (HY-15230) for binding to Hsp90 and regulates the function of this molecular chaperone. PU-20F induces the degradation of oncogenic Her2 tyrosine kinase. PU-20F blocks the growth of breast cancer cells. PU-20F can be used in breast cancer-related research[1].
In Vitro:PU-20F (compound 59) competes with geldanamycin for binding to purified Hsp90 protein with an EC50 of 6.8 μM[1].
PU-20F (compound 59) (72 h) inhibits the growth of MCF-7 human breast cancer cells with an IC50 of 23 μM[1].
PU-20F (compound 59) induces degradation of Her2 tyrosine kinase in MCF-7 human breast cancer cells with an IC50 of 20 μM[1].
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- PU-20F
- Cat. No.:
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