SW083688
CAS No. : 422281-45-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $360 | In-stock |
| 10mg | $575 | In-stock |
| 25mg | $1150 | In-stock |
| 50mg | $1850 | In-stock |
| 100mg | $2950 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-122232 |
| M.Wt: | 455.53 |
| Formula: | C23H25N3O5S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
SW083688 is a selective TAOK2 inhibitor with an IC50 of 1.3 μM. SW083688 increases the abundance of p62 protein, inhibits autophagosome maturation, and blocks Autophagic flux. SW083688 is applicable for the research of non-small cell lung cancer and pancreatic cancer[1][2].
IC50 & Target:TAOK 2 (IC50 of 1.3 μM)[1]
In Vitro:SW083688 inhibits TAOK2 activity in both cell-free and cell-based in vitro systems, suppresses autophagy by increasing p62 levels and, together with SW034538, impairing MAP1LC3A/B processing, and supports TAOK2's positive role in autophagy[1].
SW083688 is highly specific for TAOK2, with significant inhibition only of TAOK2 across a panel of 45 kinases[2].
SW083688 inhibits purified TAOK2 kinase activity with an IC50 of 1.3 μM in a radiometric assay[2].
SW083688 (50 μM; 24 h) significantly impairs autophagic flux in U2OS cells stably expressing GFP-LC3, as shown by increased GFP-LC3 accumulation and p62 protein abundance[2].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- SW083688
- Cat. No.:
- HY-122232
- Quantity:
Your information is safe with us.